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Recent discoveries suggest that the gene Astrocyte elevated gene-1 (AEG-1) could even be controlled with certain therapies to prevent or reverse obesity and obesity-related cancers.
"This is a completely new function of AEG-1, and we did not expect this," said Devanand Sarkar, Ph.D., Harrison Endowed Scholar in Cancer Research and member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center, associate professor in the Department of Human and Molecular Genetics at the VCU School of Medicine and member of the VCU Institute of Molecular Medicine.
AEG-1 interacts with a variety of proteins to regulate genetic functions related to vitamins, hormones and lipids. Sarkar and his colleagues have been studying the gene for years, investigating its role in disease formation and metabolism.
Last year, they showed that AEG-1 blocks the ability of Vitamin A to kill liver cancer cells. The team is delving deeper with its research as documented in a series of papers recently published online in the Journal of Biological Chemistry and Bioconjugate Chemistry.
In one paper, the team describes the creation of a novel therapy that inhibits AEG-1 and stops the growth of liver cancer cells.
In another, they show that AEG-1 blocks thyroid hormone function and contributes to nonthyroidal illness syndrome, a condition common in patients with liver cancer and others who are starving or gravely ill.
And in the third, the team details its finding that AEG-1 may play a key role in regulating fat metabolism.
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